A journal that publishes papers on a broad range of topics of general interest to those working on the nervous system
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Journal of Neuroscience recent issues
High-Pressure Freezing EM Tomography of Entire Ribbon Synapses in the Retina
In the retina, presynaptic active zones in photoreceptors and bipolar cells are distinguished by a plate-like "ribbon" linked to the plasma membrane (PM) and surrounded by dozens of synaptic vesicles (SVs) tethered to it. SVs at the base of the ri...
Author: Zhang, J., Aronova, M. A., Yu, X., Sousa, A. A., Leapman, R. D., Diamond, J. S.
Posted: December 3, 2025, 5:30 pm
Frontoparietal Hubs Leverage Probabilistic Representations and Integrated Uncertainty to Guide Cognitive Flexibility
Adaptive behavior requires integrating information from multiple sources. These sources can originate from distinct channels, such as internally maintained latent cognitive representations or externally presented sensory cues. Because these signal...
Author: Leach, S. C., Hollow, H., Jiang, J., Hwang, K.
Posted: December 3, 2025, 5:30 pm
Widely Used CaMKII Regulatory Segment Mutations Cause Tight Actinin Binding and Dendritic Spine Enlargement in Unstimulated Neurons
Ca2+/calmodulin-dependent protein kinase II (CaMKII) is essential for long-term potentiation (LTP) of excitatory synapses, a process fundamental to learning. CaMKII responds to Ca2+ influx into postsynaptic spines by phosphorylating proteins and f...
Author: Curtis, A. J., Zhu, J., Studniarczyk, D., Church, T. W., Farrant, M., Gold, M. G.
Posted: December 3, 2025, 5:30 pm
Neural Oscillation as a Selective Modulatory Mechanism on Decision Confidence, Speed, and Accuracy
Neural oscillations have been associated with decision-making processes, but their underlying network mechanisms remain unclear. This study investigates how neural oscillations influence decision network models of competing cortical columns with v...
Author: Azimi, A., Wong-Lin, K.
Posted: December 3, 2025, 5:30 pm
Ventral Striatal Cholinergic Interneurons Regulate Decision-Making or Motor Impulsivity Differentially across Learning and Biological Sex
Dopaminergic transmission within the ventral striatum is broadly implicated in risk/reward decision-making and impulse control, and the rat gambling task (rGT) measures both behaviors concurrently. While the resulting indices of risky choice and i...
Author: Hynes, T. J., Chernoff, C. S., Hrelja, K., Li, A., Betts, G. D., Calderhead, L. S., Winstanley, C. A.
Posted: December 3, 2025, 5:30 pm
Dopamine and Temporal Discounting: Revisiting Pharmacology and Individual Differences
Disorders characterized by changes in dopamine (DA) neurotransmission are often linked to changes in the temporal discounting of future rewards. Likewise, pharmacological manipulations of DA neurotransmission in healthy individuals modulate tempor...
Author: Smith, E., Theis, H., van Eimeren, T., Knauth, K., Tuzsus, D., Zhang, L., Mathar, D., Peters, J.
Posted: December 3, 2025, 5:30 pm
Mental Images from Long-Term Memory Differ from Perception: Evidence for Distinct Spatial Formats and Distinct Mechanisms of Spatial Attention Orientation
How is spatial attention deployed in mental images? Mental imagery is often assumed to share mechanisms with visual perception and visual working memory. Top-down, endogenous spatial attention in both visual perception and working memory modulates...
Author: Clement, A., Tallon-Baudry, C.
Posted: December 3, 2025, 5:30 pm
Dendrite-Targeting Inhibitory Interneurons Form Biased Circuits with Deep and Superficial Pyramidal Cells in Hippocampal CA1
In the CA1 hippocampus, pyramidal cells (PCs) can be classified as deep or superficial based on their radial position within the stratum pyramidale. Deep and superficial PCs form biased circuits with perisomatic-targeting PV+ basket cells, but it ...
Author: Johantges, A. C., Hanson, M. A., Marshall, A. H., Safa, A., Payne, E. K., Hariths, N. R., Bibi, N., Wester, J. C.
Posted: December 3, 2025, 5:30 pm
