A journal that publishes papers on a broad range of topics of general interest to those working on the nervous system
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Journal of Neuroscience recent issues
Monosynaptic Rabies Tracing Reveals Sex- and Age-Dependent Dorsal Subiculum Connectivity Alterations in an Alzheimer's Disease Mouse Model
The subiculum (SUB), a hippocampal formation structure, is among the earliest brain regions impacted in Alzheimer's disease (AD). Toward a better understanding of AD circuit-based mechanisms, we mapped synaptic circuit inputs to dorsal SUB using m...
Author: Ye, Q., Gast, G., Wilfley, E. G., Huynh, H., Hays, C., Holmes, T. C., Xu, X.
Posted: April 17, 2024, 4:30 pm
Neuronal Ensembles in the Amygdala Allow Social Information to Motivate Later Decisions
Social experiences carry tremendous weight in our decision-making, even when social partners are not present. To determine mechanisms, we trained female mice to respond for two food reinforcers. Then, one food was paired with a novel conspecific. ...
Author: Kietzman, H. W., Trinoskey-Rice, G., Seo, E. H., Guo, J., Gourley, S. L.
Posted: April 17, 2024, 4:30 pm
Defining Overlooked Structures Reveals New Associations between the Cortex and Cognition in Aging and Alzheimer's Disease
Recent work suggests that indentations of the cerebral cortex, or sulci, may be uniquely vulnerable to atrophy in aging and Alzheimer's disease (AD) and that the posteromedial cortex (PMC) is particularly vulnerable to atrophy and pathology accumu...
Author: Maboudian, S. A., Willbrand, E. H., Kelly, J. P., Jagust, W. J., Weiner, K. S., for the Alzheimers Disease Neuroimaging Initiative
Posted: April 17, 2024, 4:30 pm
Human Motor Neurons Elicit Pathological Hallmarks of ALS and Reveal Potential Biomarkers of the Disease in Response to Prolonged IFN{gamma} Exposure
Amyotrophic lateral sclerosis (ALS) is a debilitating neurodegenerative disorder marked by progressive motor neuron degeneration and muscle denervation. A recent transcriptomic study integrating a wide range of human ALS samples revealed that the ...
Author: Chun, C., Lee, J. H., Bothwell, M., Nghiem, P., Smith, A. S. T., Mack, D. L.
Posted: April 17, 2024, 4:30 pm
Single-Cell Analysis of Rohon-Beard Neurons Implicates Fgf Signaling in Axon Maintenance and Cell Survival
Peripheral sensory neurons are a critical part of the nervous system that transmit a multitude of sensory stimuli to the central nervous system. During larval and juvenile stages in zebrafish, this function is mediated by Rohon–Beard somatosensory...
Author: Tuttle, A. M., Miller, L. N., Royer, L. J., Wen, H., Kelly, J. J., Calistri, N. L., Heiser, L. M., Nechiporuk, A. V.
Posted: April 17, 2024, 4:30 pm
Recurrent Neural Circuits Overcome Partial Inactivation by Compensation and Re-learning
Technical advances in artificial manipulation of neural activity have precipitated a surge in studying the causal contribution of brain circuits to cognition and behavior. However, complexities of neural circuits challenge interpretation of experi...
Author: Bredenberg, C., Savin, C., Kiani, R.
Posted: April 17, 2024, 4:30 pm
Assessing Spontaneous Categorical Processing of Visual Shapes via Frequency-Tagging EEG
Categorization is an essential cognitive and perceptual process, which happens spontaneously. However, earlier research often neglected the spontaneous nature of this process by mainly adopting explicit tasks in behavioral or neuroimaging paradigm...
Author: Van Overwalle, J., Van der Donck, S., Van de Cruys, S., Boets, B., Wagemans, J.
Posted: April 17, 2024, 4:30 pm
Linear and Nonlinear Behaviors of the Photoreceptor Coupled Network
Photoreceptors are electrically coupled to one another, and the spatiotemporal properties of electrical synapses in a two-dimensional retinal network are still not well studied, because of the limitation of the single electrode or pair recording t...
Author: Pang, J.-J., Jiang, X., Wu, S. M.
Posted: April 17, 2024, 4:30 pm