A journal that publishes papers on a broad range of topics of general interest to those working on the nervous system
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Journal of Neuroscience recent issues
Kappa Opioid Receptors Control a Stress-Sensitive Brain Circuit and Drive Cocaine Seeking
Stress is a potent trigger for drug-seeking behaviors in both rodents and humans with a history of substance use. Kappa opioid receptors (kORs) play a critical role in mediating stress responses. Our previous studies in the ventral tegmental area ...
Author: Martinez Damonte, V., Bailey, L. G., Thakar, A., Stralka, J., Brown, T. E., Kauer, J. A.
Posted: October 22, 2025, 4:30 pm
A Neural Model for V1 That Incorporates Dendritic Nonlinearities and Backpropagating Action Potentials
The work of Hubel and Wiesel has been instrumental in shaping our understanding of V1, leading to modeling neural responses as cascades of linear and nonlinear processes in what is known as the "standard model" of vision. Under this formulation, h...
Author: Rentzeperis, I., Prandi, D., Bertalmio, M.
Posted: October 22, 2025, 4:30 pm
Mediodorsal Thalamic Input to Striatum Contributes to Early Action Learning
Action control is hypothesized to be mediated by corticothalamo-basal ganglia loops subserving the acquisition and updating of action contingencies. Within this, the mediodorsal thalamus (MD) is thought to contribute to volitional control over beh...
Author: Baltz, E. T., He, J., Gremel, C. M.
Posted: October 22, 2025, 4:30 pm
Presenilin Loss Impairs Synaptic Transmission and Causes Axonal Degeneration through Ryanodine Receptor Dysfunction, Independent of {gamma}-Secretase Activity
Presenilin mutations are the most common cause of familial Alzheimer's disease (FAD), but the mechanisms by which they disrupt neuronal function remain unresolved, particularly in relation to -secretase activity. Using Caenorhabditis elegans, we s...
Author: Du, X., Niu, L., Ragan, M., Fracz, Z., Wang, Z.-W.
Posted: October 22, 2025, 4:30 pm
Convergence and Segregation of Excitatory and Inhibitory Afferents in the Paraventricular Thalamic Nucleus
The paraventricular thalamic nucleus (PVT) integrates subcortical signals related to arousal, stress, addiction, and anxiety with top-down cortical influences. Increases or decreases in PVT activity exert profound, long-lasting effects on behavior...
Author: Biro, L., Buday, Z., Kota, K., Lorincz, S., Acsady, L.
Posted: October 22, 2025, 4:30 pm
Trans-synaptic Interaction with mGluR6 Contributes to ELFN1 Presynaptic Enrichment in Rod Photoreceptors
At the glutamatergic synapses between rod photoreceptors and ON-type bipolar cells (BCs), neurotransmitter is detected by the postsynaptic metabotropic glutamate receptor mGluR6. This receptor forms trans-synaptic interactions with ELFN1, a presyn...
Author: Lee, J., McGowan, R. V., Agosto, M. A.
Posted: October 22, 2025, 4:30 pm
Smg5 Enhances Oligodendrocyte Differentiation via Nonsense-Mediated mRNA Decay of Hnrnpl Variant Transcripts
Nonsense-mediated mRNA decay (NMD) is a conserved RNA surveillance mechanism that degrades transcripts with premature termination codons (PTCs) and fine-tunes gene expression by targeting RNA transcripts with other NMD inducing features. This stud...
Author: Jiang, M., Li, C., Xie, B., Li, T., Dai, Z.-M., Qiu, M.
Posted: October 22, 2025, 4:30 pm
IGFBP2-Ceramide Pathway Mediates Divergent Myelin Breakdown in the PNS and CNS Following Injury
Following injury, the peripheral nervous system (PNS) exhibits remarkable regenerative capacity, whereas the central nervous system (CNS) has limited regenerative potential. This difference is partially attributed to distinct postinjury myelin bre...
Author: Ma, S., Fu, X., Lyu, J., Guo, W., Wang, J., Li, J., Ying, Z.
Posted: October 22, 2025, 4:30 pm
