Open access, peer-reviewed online journal dealing with circadian and nycthemeral (daily) rhythms in living organisms
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Journal of Circadian Rhythms Latest Articles
Discovery and Visualization of Age-Dependent Patterns in the Diurnal Transcriptome of Drosophila
Many critical life processes are regulated by input from 24-hour external light/dark cycles, such as metabolism, cellular homeostasis, and detoxification. The circadian clock, which helps coordinate the response to these diurnal light/dark cycles,...
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Day-Night Variations in the Concentration of Neurotransmitters in the Rat Lumbar Spinal Cord
The purpose of this study was to analyze the light-dark variations in the concentrations of several neurotransmitters in the lumbar spinal cord of rats. Six groups of male Wistar rats were exposed to a 12 h light-12 h dark cycle for 70 days. At di...
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Genes Relevant to Tissue Response to Cancer Therapy Display Diurnal Variation in mRNA Expression in Human Oral Mucosa
Background: To address a critical gap for application of cancer chronotherapy of when would be the best time(s) for treating an individual cancer patient, we conducted a pilot study to characterize diurnal variations of gene expression in oral muc...
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Changes in 24 h Rhythmicity of Spontaneous Locomotor Activity in the Triple Transgenic Mouse for Alzheimer’s Disease (3xTg-AD) in a Jet Lag Protocol: Correlations with Retinal Sensitivity
The progression of amyloid plaques and neurofibrillary tangles in different brain areas is associated with the effects of Alzheimer’s disease (AD). In addition to cognitive impairment, circadian alterations in locomotor activity have also been det...
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Tubulin Polymerization Promoting Protein Affects the Circadian Timing System in C57Bl/6 Mice
The circadian timing system (CTS) is a complex set of cyclic cellular mechanisms which serve to synchronize discrete cell groups across multiple organ systems to adapt the body’s physiology to a (roughly) 24-hour clock. Many genes and hormones hav...
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A Functional Adenosine Deaminase Polymorphism Associates with Evening Melatonin Levels and Sleep Quality
Increased adenosine levels throughout the day promote sleepiness. A single nucleotide polymorphism (SNP) in the adenosine deaminase ADA gene (rs73598374) has been shown to affect sleep regulation. The extent to which lower ADA enzymatic activity i...
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Daily and Estral Regulation of RFRP-3 Neurons in the Female Mice
Female reproductive success relies on proper integration of circadian- and ovarian- signals to the hypothalamic-pituitary-gonadal axis in order to synchronize the preovulatory LH surge at the end of the ovarian follicular stage with the onset of t...
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Regional Differences in Height, Weight, and Body Composition may Result from Photoperiodic Responses: An Ecological Analysis of Japanese Children and Adolescents
This ecological study examined whether geographical differences in the physique of Japanese children and adolescents can be explained from the perspective of photoperiodicity induced by effective day length (light duration exceeding a certain thre...
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