This section aims to increase our understanding of the neuronal underpinnings of sleep & circadian rhythms
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Frontiers in Neuroscience | Sleep and Circadian Rhythms section | New and Recent Articles
Disruptions of Circadian Rhythms and Thrombolytic Therapy During Ischemic Stroke Intervention
Several endogenous and exogenous factors interact to influence stroke occurrence, in turn contributing to discernable daily distribution patterns in the frequency and severity of cerebrovascular events. Specifically, strokes that occur during the ...
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Biologically Relevant Lighting: An Industry Perspective
Innovations in LED lighting technology have led to tremendous adoption rates and vastly improved the metrics by which they are traditionally evaluated–including color quality, longevity, and energy efficiency to name a few. Additionally, scientifi...
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Classifying Vulnerability to Sleep Deprivation Using Resting-State Functional MRI Graph Theory Metrics
Sleep deprivation (SD) has become very common in contemporary society, where people work around the clock. SD-induced cognitive deficits show large inter-individual differences and are trait-like with known neural correlates. However, few studies ...
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Cholinergic-Induced Specific Oscillations in the Medial Prefrontal Cortex to Reverse Propofol Anesthesia
General anesthesia is a drug-induced reversible state comprised of altered states of consciousness, amnesia, analgesia, and immobility. The medial frontal cortex (mPFC) has been discovered to modulate the level of consciousness through cholinergic...
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Attenuated SIRT1 Activity Leads to PER2 Cytoplasmic Localization and Dampens the Amplitude of Bmal1 Promoter-Driven Circadian Oscillation
The circadian clock possesses robust systems to maintain the rhythm approximately 24 h, from cellular to organismal levels, whereas aging is known to be one of the risk factors linked to the alternation of circadian physiology and behavior. The am...
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Orexin/Hypocretin and Histamine Cross-Talk on Hypothalamic Neuron Counts in Mice
The loss of hypothalamic neurons that produce wake-promoting orexin (hypocretin) neuropeptides is responsible for narcolepsy type 1 (NT1). While the number of histamine neurons is increased in patients with NT1, results on orexin-deficient mouse m...
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Comparative Neurology of Circadian Photoreception: The Retinohypothalamic Tract (RHT) in Sighted and Naturally Blind Mammals
The mammalian eye contains two systems for light perception: an image detecting system constituted primarily of the classical photoreceptors, rods and cones, and a non-image forming system (NIF) constituted of a small group of intrinsically photos...
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M1-Type, but Not M4-Type, Melanopsin Ganglion Cells Are Physiologically Tuned to the Central Circadian Clock
Proper circadian photoentrainment is crucial for the survival of many organisms. In mammals, intrinsically photosensitive retinal ganglion cells (ipRGCs) can use the photopigment melanopsin to sense light independently from rod and cone photorecep...
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