This section aims to increase our understanding of the neuronal underpinnings of sleep & circadian rhythms
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Frontiers in Neuroscience | Sleep and Circadian Rhythms section | New and Recent Articles
A novel theory of rapid eye movement sleep as an integral component of the seasonal timekeeping apparatus
Although we have an increasingly sure grasp of much of its proximate circuitry, we continue to lack the ultimate physiological rationale of rapid eye movement (REM) sleep. In this paper, we propose that REM sleep derives both its proximate mechani...
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Disrupted sleep-wake cycles and circadian rhythms in a Drosophila model of C9orf72-FTD
Frontotemporal dementia (FTD) is a neurodegenerative disorder that affects behavior, personality, motor activity, speech, cognition, and sleeping patterns. Previous findings support the idea that disruption of sleep and circadian systems may not o...
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The ventrolateral preoptic nucleus: a multisystem integrator in sleep–wake regulation
The ventrolateral preoptic nucleus (VLPO) of the anterior hypothalamus is a major sleep-promoting region and a key component of the networks governing sleep–wake regulation. Rather than acting as a unitary “sleep center,” the VLPO is increasingly ...
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Sleep and circadian rhythm disruptions in animal models of temporal lobe epilepsy
Temporal lobe epilepsy (TLE) is frequently accompanied by disruptions to sleep and circadian rhythms, which substantially contribute to disease burden. Human studies are often confounded by antiseizure medications, limiting insight into underlying...
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Examining circadian rhythm dysregulation using actigraphy among treatment-seeking individuals with alcohol use disorder
BackgroundIdentifying factors predictive of relapse in patients with alcohol use disorder (AUD) following a period of abstinence and/or treatment is essential to discover effective treatment plans for this disease. Previous evidence found that ind...
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Timing of exercise differentially modulates fear memory and hippocampal neurotransmitters in male rats
Exercise promotes neurogenesis and enhances memory consolidation while reducing the retention of aversive memories and anxiety-like behaviors. While our previous work found that acute exercise alters neurotransmitter concentrations, including dopa...
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A narrative review on oxytocin at the intersection of sleep, stress, and social behavior
Sleep, stress regulation, and circadian rhythms form an interdependent network that shapes cognition, emotion, and social behavior. Disruption of any component can amplify stress sensitivity and impair emotional regulation, leading to neurobehavio...
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