This section aims to increase our understanding of the neuronal underpinnings of sleep & circadian rhythms
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Frontiers in Neuroscience | Sleep and Circadian Rhythms section | New and Recent Articles
Acoustic stimulation and other emerging approaches to enhance sleep: design notes for the next generation of closed-loop neurostimulation technology
Sleep is indispensable to human health, supporting memory consolidation, emotional regulation, immune function, and metabolic homeostasis. Despite its importance, chronic sleep disturbances are pervasive, with especially high prevalence in operati...
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Structural and functional alterations in postmenopausal women with insomnia: an MRI study of Eight-Section Vajra Exercise intervention effects
BackgroundPostmenopausal women exhibit heightened vulnerability to chronic insomnia due to estrogen decline and age-related neural alterations. While non-pharmacological interventions are preferred for long-term management, the neuroplastic mechan...
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Depression mediated sleep disturbances and cognitive decline in Parkinson’s disease patient
ObjectiveThis study investigated the distinct mechanistic pathways linking depression, sleep disturbances, and cognitive decline in Parkinson’s disease, with emphasis on differential roles of daytime sleepiness versus rapid eye movement sleep diso...
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Sleep regulation in Drosophila: a review of neural circuits and genetics
Sleep in Drosophila melanogaster is regulated by a complex and distributed network of neural circuits that are influenced by factors such as internal state, circadian timing, and prior experiences. While no single “sleep center” has been identifie...
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Cortical excitability and brain function in patients with insomnia: a pilot transcranial magnetic stimulation and functional near-infrared spectroscopy study
BackgroundInsomnia significantly impairs well-being, cognitive function, and social functioning, yet subjective psychological assessments often yield equivocal results regarding the extent of this impairment. Neural function may underlie this disc...
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Insomnia treatment based on the regulation of the GABAergic system: traditional Chinese medicine perspectives and therapeutic approaches
Insomnia is a common clinical manifestation of central nervous system (CNS) dysfunction that may be attributable to the involvement of abnormalities in multiple systems. Dysfunction of the gamma-aminobutyric acid (GABA) system is one of the key pa...
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Circadian and sleep–wake rhythm alterations in isolated REM sleep behavior disorder: biomarkers of prodromal α-synucleinopathy
Growing evidence highlights a tight interplay linking circadian and sleep–wake disturbances to the pathophysiology of neurodegenerative disorders. In α-synucleinopathies, three key points have emerged: (1) circadian and sleep–wake disruptions may ...
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Mechanism study of exercise intervention on circadian disruption in Alzheimer’s disease
Alzheimer’s disease (AD) induces profound circadian disruption—characterized by suprachiasmatic nucleus (SCN) degeneration, Aβ and tau pathology, and aberrant melatonin secretion which results in fragmented sleep–wake cycles and cognitive decline....
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