This section aims to increase our understanding of the neuronal underpinnings of sleep & circadian rhythms
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Frontiers in Neuroscience | Sleep and Circadian Rhythms section | New and Recent Articles
Age-related and sex-specific trends in sleep quality in children and adolescents
IntroductionStrong developmental trends are well described in non-rapid eye movement (NREM) sleep characteristics but also seen in cyclic-alternating-pattern (CAP). The latter shows a bimodal distribution: slow wave dominant (A1) complexes early i...
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The effects of sleep deprivation on cognitive flexibility: a scoping review of outcomes and biological mechanisms
BackgroundSleep is vital for physical and mental health, yet sleep deprivation is a widespread issue that may impair cognitive flexibility, leading to rigid thinking and slower decision-making. This scoping review synthesizes evidence on the impac...
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Bacterial peptidoglycan levels have brain area, time of day, and sleep loss-induced fluctuations
Sleep-inducing bacterial cell wall components isolated from brain and urine of sleep deprived animals were identified as peptidoglycan (PG) and muropeptides in the 1980s. Following host detection of PG/muropeptides, downstream signaling mechanisms...
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Dynamic changes in sleep architecture in a mouse model of acute kidney injury transitioning to chronic kidney disease
IntroductionSleep disorders are common in individuals with kidney failure. Whether kidney impairment is the direct cause of sleep abnormalities is unclear, however, partly due to confounding factors including comorbidities, dialysis, and drugs.Met...
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Editorial: Long-term effects of adolescent stress, sleep deprivation, or circadian disruption on mood and anxiety
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The circadian genes are required in DAL neurons for Drosophila long-term memory formation
We previously showed that memory formation of Drosophila olfactory avoidance can be inhibited by ubiquitous, post-training, inducible disruption of the circadian system. In this report, we limit intervention to the dorsal anterior lateral neurons,...
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Role of the clock gene homolog aha-1 in the circadian system of Caenorhabditis elegans
BackgroundCircadian rhythms are endogenous and allow organisms to adapt to external daily rhythms of light, temperature and other environmental factors. Circadian rhythms are regulated by a central clock, which is based on a transcription-translat...
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Loss-of-consciousness: sources of GABAergic input to the mesopontine tegmental anesthesia area
Exposure of neurons in the brainstem mesopontine tegmental anesthesia area (MPTA) to minute quantities of GABAergic general anesthetics at clinically relevant concentrations is sufficient to induce loss-of-consciousness (LOC), while lesioning this...
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