Articles cover sleep & circadian rhythms disorders from bench research to clinical reviews
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Frontiers in Neurology | Sleep Disorders section | New and Recent Articles
Glymphatic dysfunction across sleep disorders: a meta-analysis of DTI-ALPS studies
BackgroundSleep disorders are increasingly linked to glymphatic dysfunction, but whether this impairment is universal across different sleep pathologies remains unclear.ObjectiveThis meta-analysis examined whether glymphatic dysfunction, assessed ...
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Serum neurotransmitter imbalances in benign paroxysmal positional vertigo: correlations with anxiety, depression, and sleep quality
PurposeThis study aims to investigate the associations between serum neurotransmitter levels (dopamine, epinephrine, norepinephrine) and psychological/sleep comorbidities in patients with benign paroxysmal positional vertigo (BPPV), elucidating th...
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A novel integrated inflammatory-metabolic indicator as a potential predictor of obstructive sleep apnea: evidence from a clinical cohort and validation in the US National Health and Nutrition Examination Survey
BackgroundObstructive sleep apnea (OSA) is a prevalent sleep-disordered breathing condition closely associated with cardiovascular and metabolic risks. The current diagnostic gold standard, polysomnography, faces accessibility limitations, necessi...
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MAPK signaling pathway contributes to regulating the Nrf2 expression and compensation for hypoxia in hypoglossal nucleus induced by chronic intermittent hypoxia in rats
IntroductionTo investigate the expression of classic markers of oxidative stress and the possible triggers, the expression of Nrf2, Keap1, and MAPK pathway-related proteins (JNK, p38MAPK, ERK) were evaluated in the hypoglossal nucleus under a rat ...
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The effect of hyperbaric oxygen therapy on sleep quality across diverse patient populations
BackgroundSleep disturbances are common in aging, post-traumatic stress disorder (PTSD), and long COVID, often linked to neuroinflammation, autonomic dysregulation, and neurodegeneration. Hyperbaric oxygen therapy (HBOT) promotes neuroplasticity t...
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Effectiveness of combined versus single circadian interventions in neonatal and pediatric intensive care units: a systematic review with meta-analysis
IntroductionAdmission to neonatal or pediatric intensive care units exposes vulnerable patients to confounding environmental cues, disrupting circadian rhythms and potentially compromising physiological stability. While various circadian intervent...
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Obstructive sleep apnea, CPAP therapy, and gastroesophageal reflux symptoms: evidence from a prospective cohort study
BackgroundObstructive sleep apnea (OSA) frequently coexists with gastroesophageal reflux disease (GERD), yet the degree to which hypoxic burden contributes to reflux severity and whether symptoms improve with continuous positive airway pressure (C...
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Evaluation of sexual dysfunction and its predictors in men with obstructive sleep apnea syndrome: a multidimensional clinical and psychological approach
BackgroundObstructive sleep apnea syndrome (OSAS) is a common sleep-related breathing disorder associated with significant cardiovascular, metabolic, and neuropsychological consequences. Increasing evidence suggests that OSAS may also adversely af...
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